Course book Advanced Treatment Planning 2018

Summary

• Small dose differences make a difference (clinically) • Multi-criteria optimisation (MCO) – improved individualisation • Keep talking – dialogue = 2 way conversation

• Protons • Normal tissue response •

More data needed on normal tissue toxicity dose response • Dose accumulation in normal tissues • Biological variation in normal tissue sensitivity • Could we convolve a biological measure of individual normal tissue radiosensitivity with the physical dose plan