Course book Advanced Treatment Planning 2018
Clinical evaluation: comparison of toxicity data from different protocols
• Biologically Effective Dose
▪ A parameter that is independent from the fractionation ▪ It doesn’t express a real delivered dose
D D
d
D BED
= d
+ +
/
+
/
2
1
1
=
2
1
d
/
0
+
/
1
2
1
d D BED
d
1
1
= dN
=
+
1
+
1
3
1
1
/
/
N : fraction number d 1 : fraction number
/ : alfa-beta ratio
for the given effect
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