Course book Advanced Treatment Planning 2018
Parameters for clinical outcome: Small bowel
Small bowel toxicity in patients with GYN tumors undergone or not to abdominal surgery: 1) 95 patients with GYN malignancies 2) 34 patients after surgery, 61 patients without prior surgery 3) Use of LASSO for modeling logistic regression over Vdose parameters
−
1
4
+ = V TV
1
50
NTCP
=
1
ˆ
X
−
e
1
+
TV 50 = tolerance volume corresponding to 50% incidence of complications V = volume of small bowel receiving a given dose level = normalized slope of the volume response curve
TF Lee et al. The Different Dose-Volume Effects of Normal Tissue Complication Probability Using LASSO for Acute Small-Bowel Toxicity during Radiotherapy in
Gynecological Patients with or without Prior Abdominal Surgery. BioMed Research International Volume 2014, Article ID 143020.
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