Course book Advanced Treatment Planning 2018
Parameters for clinical outcome: Small bowel
Irradiation type (partial organ unless otherwise stated)
Volume segmented
Dose (Gy), or dose/volume parameters
Notes on dose/volume parameters
Endpoint
Rate (%)
Volume based on segmentation of the individual loops of bowel , not the entire potential peritoneal space Volume based on the entire potential space within the peritoneal cavity
Individual small bowel loops
Grade > 3 acute toxicity
3D-CRT
V15 <120 cc
<10
Entire potential space within peritoneal cavity
Grade > 3 acute toxicity
3D-CRT
V45 <195 cc
<10
• All data based on series with concurrent chemotherapy • For single fraction SBRT (25 Gy) data are poor , but the cutoff seems to set down to V12.5<30 cc without bowel toxicity
Kavanagh BD et al. Radiation Dose-Volume effects in the stomach and small bowel. Int. J. Radiation Oncology Biol. Phys., Vol. 76, No. 3, Supplement, pp. S101–S107, 2010.
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