Course book Advanced Treatment Planning 2018
Parameters for clinical outcome: Rectum
Irradiation type (partial organ unless otherwise stated)
Dose (Gy), or dose/volume parameters
Volume segmented Whole organ
Notes on dose/volume parameters
Endpoint
Rate (%)
3D-CRT
V50 <50%
Grade > 2 late rectal toxicity, Grade > 3 late rectal toxicity Grade > 2 late rectal toxicity, Grade > 3 late rectal toxicity Grade > 2 late rectal toxicity, Grade > 3 late rectal toxicity Grade > 2 late rectal toxicity, Grade > 3 late rectal toxicity Grade > 2 late rectal toxicity, Grade > 3 late rectal toxicity
<15 <10 <15 <10 <15 <10 <15 <10 <15 <10
Whole organ
3D-CRT
V60 <35%
Whole organ
3D-CRT
V65 <25%
Prostate cancer treatment
Whole organ
3D-CRT
V70 <20%
Whole organ
3D-CRT
V75 <15%
• Rectal segmentation from above the anal verge to the turn into sigmoid colon • The evaluation of rectal bleeding seems to have an a higher lower than other endpoints (11) • The reduction of V75 from 15% to 10% is more effective than reduction of V50 from 50% to 45% respectively
Michalski JM et al. Radiation Dose-Volume effects in radiation-induced rectal injury. Int. J. Radiation Oncology Biol. Phys., Vol. 76, No. 3, Supplement, pp. S123–S129, 2010.
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