Course book Advanced Treatment Planning 2018

Motivation

• accuracy of dose calculations is crucial to quality of treatment planning and consequently to doses delivered to patients • evidence exists that dose differences on the order of 7% are clinically detectable. Moreover, several studies have shown that 5% changes in dose can result in 10%−20% changes in tumor control probability (TCP) or up to 20–30% changes in normal tissue complication probabilities (NCTP) • The problem is: ➢ To model the treatment machine ( source models or MC ) ➢ To model dose deposition in patient