Course book Advanced Treatment Planning 2018

DOSE CONSTRAINTS FOR SBRT OF CENTRAL LC

➢ Maximum tolerated doses and optimum fractionation for mediastinal structures is currently unknown

➢ Toxicity for SBRT delivered to central tumors is not well documented

➢ Serious doubts in the validity of available data, mostly coming from retrospective series with small sample sizes

➢ Lacking, incomplete or inconsistent reporting on dose specification

➢ Questionable use of EqD2, α/ß-ratios, LQM estimates

Summary of current experiences in dose/ fraction - toxicity coherences after SBRT to the mediastinal structures that lead to LungTech normal tissue constraints

German Cancer Consortium (DKTK)