Course book Advanced Treatment Planning 2018
Radiobiological dose-response models
▪ Mechanistic models : radiobiological basis
▪ energy deposition in tissue → clinical/biological effect
▪ adequate mechanistic models are hard to construct…
▪ Empirical/phenomenological models
▪ describe observed clinical effect as dose-response relationship
▪ find a way to substitute lack of biological knowledge with
clinical experience: “let the data speak”
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