Course book Advanced Treatment Planning 2018

Radiobiological dose-response models

▪ Mechanistic models : radiobiological basis

▪ energy deposition in tissue → clinical/biological effect

▪ adequate mechanistic models are hard to construct…

▪ Empirical/phenomenological models

▪ describe observed clinical effect as dose-response relationship

▪ find a way to substitute lack of biological knowledge with

clinical experience: “let the data speak”