Course book Advanced Treatment Planning 2018

Conclusions

▪ Physical optimisation using quadratic cost functions to penalize the dose deviations seems practical, but may be too optimistic in meeting the clinical objective

▪ Radiobiological optimisation will become more trustworthy by judicious use of more accurate dose-response models

▪ Physico-biological optimisation can generate plans that are clinically recognized and fulfill the dose and dose-volume constraints based on clinical practice, while outperforming physically optimised plans

Special acknowledgements to Aswin Hoffmann who kindly provided many slides