IMRT 2018

SBRT in patients with idiopathic pulmonary fibrosis

Study

Idiopathic pul. fibrosis

SBRT dose Radiation penumonitis

Yamashita Radiation Oncology 2007 Takeda Lung cancer 2015

G3 25% G5 25%

16%

4 x 12Gy

16%

4 x 12Gy G2-5 19%

Ueki JTO 2015

13%

4 x 12Gy G3+ 55%

G2+ 50% G5 17% G3+ 32% G5 21%

Yoshitake Anticancer Res 2015

8%

Bahig PRO 2016

6%

5 x 12- 14Gy

Hara J Radiat Res 2016

25%

G5 17%

➢

High risk of severe pneumonitis after SBRT ➢ Similiar risk factors for surgery (Chida 2012, Sato 2014)