IMRT 2018

SWOG 1206: Veliparib plus ChemoRT in Stage III NSCLC

Schema: Randomized Phase II

Stage IIIA/B NSCLC

Carboplatin AUC 6 day 1

Chest RT (63 Gy) weeks 1 – 7

Paclitaxel 200 mg/m 2 day 1

R A N D O M I

Unresectable

Paclitaxel 45 mg/m 2 Qw, weeks 1-7

Veliparib 80 mg BID

4–6 wks

ECOG PS 0/1

Carboplatin AUC2 Qw, weeks 1-7

po days 1-7 *

No prior therapy

Q 3 weeks x 2 cycles

Veliparib twice daily po, weeks 1-7*

Stratification:

Carboplatin AUC 6 day 1

Chest RT (63 Gy) weeks 1 – 7

4–6 wks

• PS (0 vs 1)

Paclitaxel 200 mg/m 2 day 1

Z E

Paclitaxel 45 mg/m 2 Qw, weeks 1-7

• Histology (SCCA vs Non-SCCA) • Weight loss (<5% vs >5%)

Placebo BID po days 1-7

Carboplatin AUC2 Qw, weeks 1-7

Placebo twice daily po, weeks 1-7*

* Biopsy by bronchoscopy at 2 weeks

N=188 (94 per arm)