IMRT 2018

Levels of Evidence of NTCP Models

Level

Description

NTCP model with evaluation of model performance in an independent dataset of at least one other institute (external validation) NTCP model with evaluation in an independent dataset of the same investigators/institute, but using a subsequent cohort NTCP model based on one dataset with internal validation using re- sampling techniques (e.g. bootstrapping or cross validation)

1a

1b

2

3

NTCP model with evaluation of performance using the same dataset

4

NTCP model without internal and external validation

Localio AR, Stack CB. TRIPOD: A New Reporting Baseline for Developing and Interpreting Prediction Models. Ann Intern Med. 2015;162:73–74. doi: 10.7326/M14-2423.