IMRT 2018

Cochlea Dose-Volume Effect Models

▪ Information of dose-response modeling is very limited ▪ Increased toxicity has been observed in patients treated with both adjuvant and concurrent cisplatin-RT ▪ QUANTEC recommendation: keep the dose below 35-45Gy ▪ Because a threshold for SNHL cannot be determined from the present data,

to prevent SNHL the dose to the cochlea should be kept as low as possible

Bhandare N, Jackson A, Eisbruch A, Pan CC, Flickinger JC, Antonelli P, Mendenhall WM. Radiation therapy and hearing loss. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S50-7.