HSC Section 6 Nov2016 Green Book

Original Investigation Research

Age and Proton Pump Inhibitor Treatment

than in younger patients. Furthermore, older patients are more likely not to respond to PPI therapy than younger patients.

Although there was no significant difference in the objec- tive findings among the different age groups, the subjective severity of LPR in geriatric patients is significantly greater

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ARTICLE INFORMATION Submitted for Publication: July 2, 2013; final revision received August 18, 2013; accepted September 7, 2013. Published Online: November 7, 2013. doi:10.1001/jamaoto.2013.5556. Author Contributions: Dr Eun had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Y. C. Lee, Kim, Kwon, Eun. Acquisition of data: Y. C. Lee, J. S. Lee, Kim, Kwon, Eun. Analysis and interpretation of data: Y. C. Lee, J. S. Lee, Eun. Drafting of the manuscript: Y. C. Lee, J. S. Lee. Critical revision of the manuscript for important intellectual content: Kim, Kwon, Eun. Statistical analysis: Y. C. Lee, J. S. Lee . Study supervision: Kim, Kwon, Eun. Conflict of Interest Disclosures: None reported. REFERENCES 1 . Wiener GJ, Koufman JA, Wu WC, Cooper JB, Richter JE, Castell DO. Chronic hoarseness secondary to gastroesophageal reflux disease: documentation with 24-h ambulatory pHmonitoring. Am J Gastroenterol . 1989;84(12):1503-1508. 2 . Fraser AG. Review article: gastro-oesophageal reflux and laryngeal symptoms. Aliment Pharmacol Ther . 1994;8(3):265-272. 3 . Rees CJ, Belafsky PC. Laryngopharyngeal reflux: current concepts in pathophysiology, diagnosis, and treatment. Int J Speech Lang Pathol . 2008;10(4): 245-253. 4 . Koufman J, Sataloff RT, Toohill R. Laryngopharyngeal reflux: consensus conference Gastroesophageal reflux disease in the elderly: more severe disease that requires aggressive therapy. Am J Gastroenterol . 1995;90(7):1053-1057. 6 . Brunnen PL, Karmody AM, Needham CD. Severe peptic oesophagitis. Gut . 1969;10(10):831-837. 7 . el-Serag HB, Sonnenberg A. Associations between different forms of gastro-oesophageal report. J Voice . 1996;10(3):215-216. 5 . Collen MJ, Abdulian JD, Chen YK.

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