HSC Section 6 Nov2016 Green Book

Richards AL, Sugumaran M, Aviv JE, et al. The utility of office-based biopsy for laryngopharyngeal lesions: comparison with surgical evaluation. Laryngoscope . 2015; 125(4):909-912. EBM level 4......................................................................................70-73 Summary: Office biopsy for laryngopharyngeal lesions may offer early detection and avoid operative intervention in some cases; however, for suspected dysplastic or malignant lesions, direct microlaryngoscopy should be the standard of care to ensure adequate full-thickness sampling and staging. For benign pathology, office biopsy is a safe and viable alternative to direct microlaryngoscopy and biopsy/excision.

Verma SP, Dailey SH. Office-based injection laryngoplasty for the management of unilateral vocal fold paralysis. J Voice . 2014; 28(3):382-386. EBM level 4............74-78

Summary: This study is a retrospective chart review of 82 consecutive office-based injection laryngoplasty (OBIL) attempts on 57 patients. The most common route of access was transoral (85.6%). All OBILs were able to be completed. Injectates used were hyaluronic acid derivatives (57.3%), calcium hydroxyapatite (16%), and Cymmetra (16.5%). Three complications (3.7%) occurred. Thirty percent of patients ultimately elected for thyroplasty or ansa reinnervation, 22% found their condition to self-resolve, 14% died, and 25% were lost to follow-up. D. Aging Larynx Branco A, Todorovic Fabro A, Gonçalves TM, Garcia Martins RH. Alterations in extracellular matrix composition in the aging larynx. Otolaryngol Head Neck Surg . 2015; 152(2):302-307. EBM level 4............................................................................79-84 Summary: This cadaver study proposes to further characterize extracellular matrix composition (ECM) changes in the aged vocal fold. Through immunohistochemistry, an overall increase in ECM mediated by increased collagen as well as decreased elastin were demonstrated. This work further highlights the histologic changes responsible for age-related voice changes. Lee YC, Lee JS, Kim SW, et al. Influence of age on treatment with proton pump inhibitors in patients with laryngopharyngeal reflux disease: a prospective multicenter study. JAMA Otolaryngol Head Neck Surg . 2013; 139(12):1291-1295. EBM level 4...........................................................................................................................85-89 Summary: The authors aim to evaluate differences in laryngopharyngeal reflux (LPR) symptom severity among different age cohorts as well as response to treatment. The authors demonstrate that patients over 60 years of age experience greater symptoms and impact on quality of life from LPR; however, they seem to achieve less benefit from proton pump inhibitor therapy. Yamauchi A, Yokonishi H, Imagawa H, et al. Vocal fold vibration in vocal fold atrophy: quantitative analysis with high-speed digital imaging. J Voice . 2015; 29(6):755-762. EBM level 2..................................................................................................................90-97

Summary: This study shows that high-speed digital imaging gives more insight into characterizing atrophic vocal folds.

Zeigler A, Verdolini Abbott K, Johns M, et al. Preliminary data on two voice therapy interventions in the treatment of presbyphonia. Laryngoscope . 2014; 124(8):1869-1876. EBM level 2b..............................................................................................................98-105

Summary: Zeigler et al demonstrate that vocal function exercise and PhoRTE voice therapy techniques appear to be effective in atrophy patients.