Molecular Imaging 2017

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PET-NECK

A multi-centre, randomized, phase III, controlled trial (RCT) comparing PETCT guided active surveillance with planned neck dissection (ND) for locally advanced (N2/N3) nodal metastases (LANM) in patients with head and neck squamous cell cancer (HNSCC) treated with primary radical chemoradiotherapy (CRT). Mehanna et al., University of Birmingham, J Clin Oncol 33, 2015 (suppl; abstr 6009)

Inclusion Patients with Tx-4 N2-3 cancer Eligible for CCRT and LND (before or after)

Randomization Arm 1: Planned LND before or after CCRT (control) Arm 2: CCRT with LND only based on PET (intervention) Primary outcome OS with follow-up 2Y Non-inferiority design