Molecular Imaging 2017

MR spectroscopic imaging for dose-painting in newly diagnosed GBM - Take Home Message

• Predictive value of MR spectroscopy with CHO/NAA>2 is well-known and of LAC/NAA> 0.4 was recently described .

• 170 patients have been already included in SPECTRO GLIO , a prospective multicentric clinical dose-painting trial MR spectroscopy volumes of CHO/NAA > 2 comparing standard 60 Gy with SIB IMRT at 72 Gy

• From the ongoing SPECTRO GLIO trial, longitudinal spectroscopy, perfusion and diffusion MRI studies will allow the confirmation and/or definition of new Biological Target Volume(s) for further dose-painting trials

MR spectroscopic imaging for dose-painting

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