Molecular Imaging 2017

Proliferation Metabolism

b800

ADC

Diffusion weighted MRI Assessment of water diffusion

Informs on cell density, extracellular space tortuosity & integrity of cellular membranes

Diffusion weighted MRI

1H-MRI Spectroscopy Informs on cellular membrane turnover

Choline: 3.2ppm

Common metabolites: Choline: Cell membrane synthesis & degradation Creatine: Metabolism Free Lipids: necrosis & apoptosis

Water: 4.7ppm

Lipid: 0.9-2.2ppm

MRI Spectroscopy