Molecular Imaging 2017

Can ADC differentiate malignant from benign nodes?

Author, Yr

Pts

B values

Nodes

Findings: ADC

Surgery alone Heijnen et al 2013

NM: 1.04 ± 0.22; M: 1.15± 0.24 X10 -3 Cut off 1.07 X10 -3 : Sn 67%, Sp 60%, PPV 18%, NPV 93% NM: 1.1 ± 0.22; M: 0.9± 0.15 X10 -3 Cut off 1 X10 -3 : Sn 78%, Sp 67%, PPV 61%, NPV 82% NM: 1.19 ± 0.27; M: 1.43 ± 0.38 X10 -3 Cut off 1.25 X10 -3 : Sn 53%, Sp 82%, PPV 35%, NPV 91% NM: 1.13 ± 0.23; M: 1.36 ± 0.27 X10 -3 Cut off 1.25 X10 -3 : Sn 66%, Sp 72%, PPV 46%, NPV 87%

n=21 1.5T:

Total: 212 Met: 16

0,500,1000

Cho et al 2013

n=34 1.5T: 0,1000 Total: 114 Met: 46

Pre-operative chemoradiation therapy Lambregts et al 2011 n=30 1.5T: 0,500,1000

Total:222 Met: 34

Kim et al 2014

n=59 1.5T: 0,1000 Total: 115 Met: 29

Heijnen LA et al. Eur Radiol 2013; 23(12): 3354-60; Cho EY et al. Eur J Radiol 2013; 82 (11): 662-8; Lambregts DM et al. Eur Radiol 2011; 21 (12): 2567-74; Kim SH et al. Acta Radiol 2014; Nov 25 Epub