Molecular Imaging 2017

GLIAA Study

Arm A (Experimental Intervention) PTV definition according to FET-PET:

GTV = AA uptake PET (CTV) = GTV + 3 mm, (PTV) = CTV + 1-2mm

High precision re-irradiation: 39 Gy; 3 Gy/d 5x/w

Arm B (Control Intervention) PTV definition according to CET1-MRI: GTV = CE in T1

(CTV) = GTV + 3 mm, (PTV) = CTV + 1-2mm

Oehlke O et al. (2016) Amino-acid PET versus MRI guided re-irradiation in patients with recurrent glioblastoma multiforme (GLIAA) - protocol of a randomized phase II trial (NOA 10/ARO 2013-1). BMC Cancer 16:769