Molecular Imaging 2017
P rostate- S pecific M embrane A ntigen ( PSMA )
• PSMA,
also known as
Glutamate
carboxypeptidase II , is a type II transmembrane glycoprotein (Upon ligand binding PSMA is internalized with bound molecules) • PSMA is expressed in a number of tissues including prostate, kidney, and both the central and peripheral nervous systems. • PSMA is an established cancer marker. In particular, it is upregulated in prostate cancer and has proven to be an effective diagnostic and prognostic indicator of cancer. • Ideal for developing targeted radiopharmaceuticals (fast blood clearance and low background activity)
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