ClearLLab LS CaseBook

This CD10/CD20 dot plot is gated on Lymphocytes. Note that no distinct CD20positive population is discernible in this display, consistent with the low density CD20 expression that is typical of chronic lymphocytic leukemia.

This CD20/CD19 dot plot is gated on Lymphocytes. The B lymphocytes do not display the expected normal co-expression of CD19 and CD20. Instead, virtually all of the B lymphocytes display lower than usual CD20 expression. This finding is typical of chronic lymphocytic leukemia/small lymphocytic lymphoma.

This CD19/CD10 dot plot is gated on Lymphocytes. No aberrant population is apparent in this display, although it is present and comprises the majority of the CD19 positive cells in this case.

This CD34/CD10 dot plot is gated on Lymphocytes. These cells are essentially negative for both markers, as expected for both normal mature peripheral blood lymphocytes as well as mature lymphoproliferative disorders such as chronic lymphocytic leukemia/small lymphocytic lymphoma.

NeoplasticProcessofBcellOrigin > Chronic lymphocytic leukemia/small lymphocytic lymphoma > Case#6:ChronicLymphocyticLeukemia/SmallLymphocyticLymphomaLymphocyticLymphoma

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50 Beckman Coulter • ClearLLab LS Casebook