ESTRO 2021 Abstract Book

S1089

ESTRO 2021

ongoing. The following variables were included: number of patients, treatment intention, total dose, dose per fraction, fraction per treatment, and number of fractions. We divided the fractionation schemes into normofractionation (NF) (1.8 to 2,2 Gy) and hypofractionation (HF) (> 2,2 Gy) including ultra-HF (UHF) (≥7.25 Gy). Finally, we analyzed the number of fractions divided by the total number of patients. It was defined as "Fractionation Index" (FI). All information was collected from radiotherapy records (ARIA, Varian Medical Systems) and analyzed in Microsoft's Excel database. Results A total of 372 patients of PC were treated in the period reviewed, with 70 years-old as mean age (range 45 - 83).

In 2020 there was an 11.6% absolute increase in proportion of definitive RT (Table 1). Furthermore, the definitive/post-operative ratio was of 2.83 compared to 1.65 in 2019. The most common post-operative (PORT) and definitive RT fractionation in 2019 were 68 Gy/34 Fx and 78 Gy/39 Fx respectively. These schedules decreased markedly the following year, going to 62.5 Gy/25Fx in PORT and 60 Gy/30 Fx in definitive intention. Despite definitive 70 Gy/28 Fx fractionation was adopted in 2019, its use increased in 2020 (22.5% vs 27%). Another RT scheme adopted in the lasted year were UHF (36.25 Gy/5 Fx) with stereotactic body radiation therapy technique (Figure 1).

The FI in PORT and definitive RT were 28.77 and 22.93 fractions per patient respectively in 2020, compared with 33.78 and 33.19 in 2019.

Conclusion The implementation of HF schemes in PC contributed to a more efficient management of this disease (fewer fractions per patient, FI) in a year marked by movement restrictions and less non-covid-19 outpatient clinics.