ESTRO 2021 Abstract Book

S1309

ESTRO 2021

Conclusion Implementation of 3D in-vivo dosimetry for preclinical research with small animals seems to be feasible on 3D- printed mouse phantom model. It can be safely used in real preclinical treatment to verify delivered dose to target volume. PO-1584 Development of the patient-specific phantom of the human arm part using 3D printing S. Stuchebrov 1 , A. Bulavskaya 1 , Y. Cherepennikov 2 , A. Grigorieva 1 , I. Miloichikova 2,3 1 Tomsk Polytechnic University, Research School of High-Energy Physics, Tomsk, Russian Federation; 2 Tomsk Polytechnic University, School of Nuclear Science & Engineering, Tomsk, Russian Federation; 3 Cancer research institute of Tomsk national research medical center of the Russian academy of sciences, Radiotherapy department, Tomsk, Russian Federation Purpose or Objective The international recommendation on radiation therapy quality requires high accuracy of dose delivery relative to the prescribed value. The most common approach to dose control involves clinical dosimetry procedures and radiation plan verification using nonspecific tissue equivalent phantoms. However, this approach involves many assumptions and does not take into account individual anatomical parameters. In difficult clinical cases, when critical organs are under risk of exposure, it is necessary to apply individually manufactured patient-specific phantoms. Authors propose to produce patient-specific phantoms using rapid prototyping with predetermined electron density. The aim of this study is to make patient-specific phantom of the human arm part precisely representing tissue shapes, sizes and electron density. Materials and Methods Phantom is developed on the basis of a patient’s tomography data, obtained at Cancer research institute of Tomsk NRMS RAS via Siemens Somatom Emotion 6 computed tomography (CT) system. Tomography data are used to develop 3D model of a patient’s arm using Slicer and Meshmixer software. We distinguish four volumes with different CT-indices: adipose tissue, muscle tissue, bone tissue, bone marrow tissue. As phantom materials, we use conventional PLA-plastics and PLA-plastics modified by copper powder admixture. This phantom is made using 3D printer Prusa i3 Multi Material 2.0. The phantom is separated to set of cuts with 10 mm thicknesses each. This approach is supposed to be used for dosimeters positioning into the phantom. As a final stage of the study, CT of developed phantom was performed and results were compared with initial CT- data.