ESTRO 2021 Abstract Book

S3

ESTRO 2021

Teaching lecture: Diffusion MRI: How to get started

SP-0009 Diffusion MRI: How to get started R. Tijssen 1 1 Catharina Hospital Eindhoven, Radiation Oncology, Eindhoven, The Netherlands

Abstract Text Synopsis

In this lecture we will cover the basics of Diffusion Weighted Imaging (DWI). The origin of the signal is explained as well as the most common acquisition methods. Rather than providing step-by-step recipe on how to set up a DWI scan protocol, this lecture aims to establish the underlying understanding of DWI that a physicist should have. We will discuss the potential pitfalls of this imaging technique (e.g., geometric accuracy) and cover the current status of DWI in radiotherapy (both clinical and investigational).

Target audience (Medical) physicists working in the field of radiotherapy.

Prior knowledge Some basic understanding of MR physics is required. Attendees should be familiar with basic signal formation and space encoding in MRI.

Highlights - Diffusion MRI probes tissue microstructure

- The diffusivity is measured by varying the magnetic field gradients - The most common imaging readout is Echo Planar Imaging (EPI) - EPI is prone to geometric distortion along the phase encode direction - DWI is clinically used for GTV delineation and detection of metastatic lymph nodes in various tumor sites - Tumor response assessment and prediction by DWI are explored in research setting

Teaching lecture: The role of RTT leadership in advancing multi-disciplinary research

SP-0010 The role of RTT leadership in advancing multi-disciplinary research M. Velec 1 1 Princess Margaret Cancer Centre, Radiation Medicine Program, Toronto, Canada

Abstract Text RTTs have a unique contribution to multi-disciplinary radiation oncology research. The profession has dual insight into the provision of technically precise radiotherapy and into the daily experience of patients over their cancer journey. RTT research leaders are best poised to ask the clinical and scientific questions most relevant to RTT practice. In research roles, RTTs are often at the vanguard of technological advancements. Continuous innovations in imaging, planning and delivery necessitate the testing, evaluation, of these techniques prior to clinical deployment. In the implementation phase, research RTTs can lead protocol development and staff training to ensure safe application. Collaborating with the primary developers, often physicists and vendors, in this manner means RTTs are therefore critical in translating these advancements safely to the clinic. In the clinical trials setting, evidence continues to emerge that the quality of radiotherapy can have a significant impact on clinical outcomes and the success or failure of such trials. Engaging RTTs early in the design and execution of radiotherapy trials can ensure study procedures are executed by frontline RTTs in a manner that meets stringent QA requirements. This is particularly important in large co-operative multi-centre trials that require the credentialling of high-precision approaches such VMAT, SABR, and adaptive therapy. RTTs should be included in the multi-disciplinary trial teams to ensure the highest radiotherapy quality is consistently conducted within trials. RTTs as managers, administrators other clinical practice leaders can advance multi-disciplinary research at the institutional level through the promoting the development of research leadership skills in the RTT workforce, and providing research resources (e.g. protected research time, biostatistical support). Perhaps most importantly, RTTs leadership can best advocate that RTTs ‘have a seat at the table’ in the multi-disciplinary environment. The pathway of RTTs in assuming the role of principal investigator has also matured as more RTTs complete research and doctoral degrees. In this role, the RTT independently assumes the lead of the lab or research group. They may be responsible for securing external grant funding, managing project finances, advancing research agreements (e.g. data sharing, ethics board approvals), and supervising research staff and trainees. Initiating collaborations with other multi-disciplinary researchers to complement therapist’s expertise is critical for building a successful clinical research program. There are numerous opportunities for RTTs to engage in multidisciplinary research. Leading can range from informal RTT efforts to translate advances to the clinic, to formally leading research projects as an independent investigator. These initiatives should complement and integrate with other multi-disciplinary researchers to maximize their impact.