ESTRO 2021 Abstract Book

S158

ESTRO 2021

Conclusion TROG 14.04 confirmed the reduction in mean heart dose using DIBH in patients with left sided breast cancer undergoing radiotherapy. Anxiety scores among DIBH patients suggested that breath holding or knowledge of the purpose of DIBH might increase patient anxiety. Further research is needed regarding anxiety triggers and to improve set-up reproducibility.

Sunday 29 August 2021

Teaching lecture: Biomarker-guided precision radiotherapy

SP-0226 Biomarker-guided precision radiotherapy S. Bratman USA

Abstract not available

Teaching lecture: The radiobiology of the normal brain

SP-0227 The radiobiology of the normal brain C. Limoli 1 1 University of California, Irvine, Radiation Oncology, Irvine, USA

Abstract Text Cranial irradiation has been used for decades to control CNS malignancies, and while cancer outcomes vary with disease specifics, long-term neurocognitive complications remain problematic. Cognitive assessments have identified a range of learning and memory deficits in humans that are clearly multifaceted and are known to vary with age, sex, genetics and treatment plans. While non-invasive imaging methodologies have advanced our understanding of the structural and metabolic changes that occur after irradiation, and omics platforms have provided insight into signaling pathways that are altered over time, the temporal progression of radiation-injury in the normal brain has nonetheless proven difficult to elucidate from clinical data. Pre- clinical rodent models on the other hand, have provided a platform for dissecting many responses that are clearly not feasible in humans. Consistency between species do point to commonalities involving oxidative and inflammatory pathways that have the capability to adversely impact neurotransmission at multiple levels, including changes in neurogenesis, mitochondrial metabolism, oxidative stress, complement cascade, adenosine metabolism, myelination, dendritic spine and synaptic density. Certain pre-clinical work has informed changes in the clinic, in particular, adoption of hippocampal sparing protocols to preserve cognition, largely based on an extensive literature demonstrating that radiation depletes neural precursor cells and inhibits neurogenesis. This talk will focus on the normal response of the brain to radiation exposure, with an emphasis on new insights gained from pre-clinical studies that can inform changes in radiotherapeutic treatment plans to improve quality of life metrics in brain tumor survivors.

Teaching lecture: Shifting cold to hot tumors: Interplay between radiation, cancer cells and microenvironment

SP-0228 Shifting cold to hot tumors: Interplay between radiation, cancer cells and microenvironment. S. Tubin 1 1 MedAustron Center for Ion Therapy and Research, Radiation Oncology, Wiener Neustadt, Austria

Abstract Text