ESTRO 2021 Abstract Book

S766

ESTRO 2021

(wrs3) scales were considered as further endpoints, with cut-offs for clinically significant deterioration defined as suggested by Cooks et al. (EJC 2012). Results A total of 1143 pts with complete information were available. Figure 1 shows radar plots with scores for the different scales. Physical functioning is the only scale that deteriorates at each time point (ageing effect?) in every country. Table 1 reports scores, hexagonal areas and the prevalence of wrs2/wrs3 as a function of country and time-points. The ratio of hexagonal areas “(at RT end)/(at 2-year)” is reported as an index for recovery of acute effects. Spanish Ratio (<1) shows a continuous deterioration with time. Wrs 2 and wrs3 at the end of RT were found in 31% (range 13% in ES – 45% in NH) and 16% (range 6% in ES – 23% in NH) of pts, respectively. Prevalence of wrs2 at 2 years was 23% (range 15% in IT – 28% in BE and NH), while wrs3 was 12% (range 11% in IT – 16% in NH).

Conclusion Results from the EORTC QLQ-C30 highlighted a large variability across countries in the deterioration of functional scales at the end of RT (acute/early phase), with differences highly reduced at 2 years (late phase). Of note, there is a consequential effect in the deterioration of functional scales, with about two-thirds of patients with deterioration at RT end who did not recover after 2 years.