PracticeUpdate Oncology May 2019

CONTENTS 3

COVER 18 Breast Cancer During Pregnancy Interview with Jennifer Litton MD by Tyeese L. Gaines DO

RESEARCH Editor’s picks 6 Lymphadenectomy in Patients With Advanced Ovarian Neoplasms

Comment by Annette Hasenburg Prof., Dr, med 7 Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study Comment by Axel Grothey MD 8 Neratinib and Capecitabine for Patients With HER2+ Breast Cancer and Brain Metastases Comments by Manmeet Ahluwalia MD, FACP and Reshma L. Mahtani DO

EXPERT OPINION 19 Chemotherapy for Oligometastatic Prostate Cancer Interview with Tanya B. Dorff MD by Farzanna S. Haffizulla MD, FACP, FAMWA 20 Stereotactic Radiosurgery vs Whole Brain Radiation for Patients With Four or More Brain Metastases Interview with Michael Lim MD by Aman Shah MD

21 Immunotherapy and TKIs in Stage III Lung Cancer Interview with Wilfried Eberhardt MD by Tyeese L. Gaines DO

9 Capecitabine Compared With Observation in Resected Biliary Tract Cancer 12 Talazoparib After Platinum or Cytotoxic Nonplatinum Regimens in Patients With Advanced Breast Cancer and Germline BRCA1/2 Mutations Comment by Reshma L. Mahtani DO 13 Cabozantinib in Advanced Non-Clear Cell Renal Cell Carcinoma Comment by Sumanta Kumar Pal MD 14 Increasing the Dose Intensity of Chemotherapy by More Frequent Administration or Sequential Scheduling Comment by Lee S. Schwartzberg MD, FACP 16 Two Dosing Regimens for Nivolumab in Combination With Ipilimumab in Patients With Advanced Melanoma Comment by Ari VanderWalde MD, MPH, FACP

CONFERENCE 22 The Radiation Oncology Summit: ACRO 2019 By the PracticeUpdate Editorial Team 22 Drug Targeting p53 Sensitizes Cancer Cells to Radiotherapy in Head and Neck Cancer 23 Link Between Germline Mutations and Severe Radiation Toxicity Identified 24 Tumor Grade/Size, Lymphovascular Invasion Predict Lymph Node Involvement in Early Endometrial Cancer 25 Recurrence Outside Treatment Field A Challenge With SBRT for Recurrent Head and Neck Squamous Cell Carcinoma

26 Society of Gynecologic Oncology 50th Annual Meeting on Women’s Cancer® By the PracticeUpdate Editorial Team 26 Dendritic Cell-Based Immunotherapy Appears Promising for Recurrent Ovarian Cancer 27 Lenvatinib + Weekly Paclitaxel Looks Promising for Recurrent Endometrial, Ovarian, Fallopian Tube and Primary Peritoneal Cancer 28 Olaparib and Neratinib Prove Synergistic

29 Mushroom Extract Supplementation Linked to Over 60% Eradication of HPV 30 DKN-01 Antibody Appears Promising in Wnt-Activated Recurrent Gynecologic Malignancies

in Models of HER2-Positive Ovarian Cancer, and PARP Inhibitors May Be Used Repeatedly

VOL. 3 • NO. 2 • 2019