Proefschrift Kerklaan

PEPaNIC trial

Early PN

Late PN

A

B

0.9 0.92 0.94 0.96

0.9 0.92 0.94 0.96

* P < 0.001 $ P < 0.001

* P = 0.008 $ P < 0.001

0.001 0.2 0.4 0.6 0.7 0.8

0.2 0.4 0.6 0.7 0.8

Discharged from PICU 0.001

Cumulative Proportion

Cumulative Proportion

Discharged Live from PICU

0 1 2 3 4 5 6 7 8 10 12 14 16 18 20 22 24 26 28 30

0 1 2 3 4 5 6 7 8 10 12 14 16 18 20 22 24 26 28 30

No. in PICU LatePN Early PN

No. in PICU LatePN Early PN

723 717

93 63

37 23

216 159

723 717

37 23

93 63

216 159

D

C

0.6 0.7 0.75 0.8 0.85

0.6 0.7 0.75 0.8 0.85

* P = 0.004 $ P = 0.002

* P = 0.011 $ P = 0.001

0.5 0.1 0.3 0.4

0.5 0.1 0.3 0.4

Cumulative Proportion Discharged

Cumulative Proportion Discharged from Index Hospital

Live from Index Hospital

0 1 2 3 4 5 6 7 8 10 12 14 16 18 20 22 24 26 28 30

0 1 2 3 4 5 6 7 8 10 12 14 16 18 20 22 24 26 28 30

No. in Index Hospital LatePN Early PN 723 717

No. in Index Hospital LatePN Early PN 723 717

247 219

129 107

448 310

247 219

129 107

448 310

E

F

* P = 0.007 $ P = 0.001

* P = 0.016 $ P = 0.020

0.8

0.8

7

0.3 0.4 0.5 0.6 0.7

0.3 0.4 0.5 0.6 0.7 0.1

0.1 0 1 2 3 4 5 6 7 8 10 12 14 16 18 20 22 24 26 28

Cumulative Proportion Discharged from Hospital (Index and Transferral Hospital)

Cumulative Proportion

30

0 1 2 3 4 5 6 7 8 10 12 14 16 18 20 22 24 26 28 30

Discharged Live from Hospital (Index and Transferral Hospital)

Days after Inclusion

Days after Inclusion

No. in Hospital (Index or Transferral) LatePN Early PN 723 475 717 449

No. in Hospital (Index or Transferral) LatePN Early PN 723 475 717 449

278 245

144 126

278 245

144 126

G

0 10 20 30 40 50 60 70 80 90 0.90 0.91 0.92 0.93 0.94 0.95 0.96 0.97 0.98 0.99 1.00 * P = 0.251 $ P = 0.075

Days after Inclusion Cumulative Proportion of Patients Alive

Supplementary Figure 3. Kaplan-Meier plots for the time to (live) discharge from the PICU and the hospital and for survival up to 90 days Panels A to F represent the cumulative proportions of patients discharged from the PICU (A), discharged live from the PICU (B), discharged from the hospital [index (C) and total (E)] and discharged live from the hospital [index (D) and total (F)]. For the analyses of the time to discharge, data for all patients were censored at 90 days, while non-survivors were censored at time of death. For the analyses of the time to live discharge, data were censored at 90 days with non-survivors censored at 91 days to account for death as a competing risk. For sake of clarity, only the first 30 days are shown in panels A-F. Panel G illustrates survival up to 90 days. The red lines represent the late PN group; the blue lines represent the early PN group. *univariable log-rank P-value; $ P-value adjusted in multivariable analysis.

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