Proefschrift Kerklaan

Chapter 7

Supplementary Table 8. Highest plasma concentrations during PICU stay for markers of liver dysfunction and inflammation. Mean plasma glucose concentration during PICU stay Early PN Late PN P-value Highest plasma concentration during PICU stay N=723 N=717 Liver dysfunction - mean (SEM) Highest plasma bilirubin – mg/dL (N = 1261) 1.6 (0.1) 1.9 (0.2) 0.006 Highest plasma Alkaline Phosphatase (N=1236) 195 (5) 182 (6) 0.001 Highest plasma GGT – IU/L (N = 1225) 85 (7) 64 (5) 0.003 Highest plasma ALT – IU/L (N = 1270) 85 (9) 118 (20) 0.33 Highest plasma AST – IU/L (N = 1268) 202 (28) 271 (48) 0.82 Inflammation - mean (SEM) Highest plasma CRP – mg/L (N = 1307) 87 (4) 93 (4) 0.09 Mean plasma glucose – mg/dL (N= 1391) 117 (1.5) 100 (1.2) < 0.001 PN=Parenteral Nutrition, PICU=Pediatric Intensive Care Unit, SEM= Standard Error of the Mean, GGT= Gamma-Glutamyltransferase, ALT= Alanine Aminotransferase, AST= Aspartate Aminotransferase, CRP= C-reactive protein

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