Proefschrift Kerklaan

Printing of this thesis was financially supported by the department of intensive care and paediatric surgery, Sophia Children’s Hospital-Erasmus MC, Rotterdam; InstruLabo BV (www. instrulabo.nl) & Brunschwig Chemie (www.brunschwig.nl) and:

The studies described in this thesis were (partially) supported by Fonds NutsOhra; Erasmus MC Cost-Effectiveness Research Grant (Mrace); Erasmus Trustfonds via Erasmus University Rotterdam; the Flemish Agency for Innovation through Science and Technology (IWT- TBM110685); the Methusalem Program funded by the Flemish Government (METH/08/07 and METH/14/06); the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC Advanced Grant Agreement n° 307523.

©2016, D. Kerklaan, The Netherlands, 2016

All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any formby anymeans, without prior written permission of the copyright owner. ISBN: 978-94-6233-289-8

Cover and graphic design: Robin Kerklaan

Printing: Gildeprint, The Netherlands