Proefschrift Kerklaan

Chapter 3

A

B

C

Figure 1. Bland-Altman plots for agreement a) between VCO 2 values derived from indirect calorimetry (IC) and Servo-I® measurements with a mean relative difference of 15.6% (panel A), b) between REE values derived from IC and Servo-I® measurements with a mean relative difference of 19% (Panel B), and relative differences between VCO 2 values derived from IC (Deltatrac®) and Servo-I® measurements by weight (kg) (panel C). The mean relative difference is represented by the solid horizontal line; dotted lines indicate 95% limits of agreement (panels A and B) or 10% difference between methods (panel C) In the 20 children weighing 15 kg or more, the agreement of the REE values on the Bland- Altman plot was considerably better. The mean relative difference between methods was 1.3% (p=0.668), with 95% limits of agreement of -24.6% and 27.2% (Fig. 2a). This mean relative difference in children ≥15 kg was significantly smaller than that of the Schofield-weight (-13.4%, p=0.03), Schofield-weight/height (-13.2%, p=0.03) andWHO (-15.0%, p=0.07) equations. As shown by the Bland-Altman plots (Fig. 2), limits of agreement were narrowest for Servo-I® based REE when compared with the REE based on predictive equations. In children ≥15 kg, the proportion of comparable measurements (difference ≤10% with IC- derived REE) was highest, whereas the proportion of measurements with a difference >30% was lowest for the Servo-I® based REE, when compared with proportions of the equations- based REE (Fig. 3).

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