Proefschrift_Holstein

Chapter 1

Rewarded task-switching paradigm

DAT1: reward e ect on cognitive exibility

A

B

0.1 0.2 0.3 0.4 0.5 0.6

reward cue (10 / 1 cent)

10 cent

task cue (arrow / word)

arrow

target ( task switch / repeat)

le

-0.3 -0.2 -0.1 0

(error rates)

correct! 10 cent

feedback

response deadline

9R+ 10R/10R reward e ect on switching

Striatum: reward e ect on cognitive exibility

C

D

9R carriers 10R homozygotes

4

2

0

R = 0.49, p = 0.03

(caudate nucleus) -2

0

1

2

reward e ect on switching

reward anticipation e ect in ventral striatum

E

F

PD: relative reductionof pre-synaptic dopamine cell integrity

PD: reward e ect on cognitive exibility

Posterior putamen Anterior putamen

Caudate nucleus (Cau) N. Accumbens (Nacc)

0.0 0.4 0.8

0.3

*

0.2

- 0.8 - 0.4

R = 0.71, p < 0.001

0.1

reward e ect on switching (transformed error rate) 0.2 0

0.4 0.6 0.8

pre-synaptic dopamine cell integrity (posterior putamen)

0

Nacc

AP Cau PP

18