Proefschrift_Holstein

Reward modulation of cognitive function: adult ADHD

processing (i.e. task switching) in the dorsal striatum of adult patients with ADHD, who carry the 9R ADHD risk allele. This deficit is remediated when patients are tested ON methylphenidate. These findings demonstrate an important role for both reward motivation as well as inter-individual trait differences in striatal dopamine transmission in cognitive processing deficits in adult ADHD.

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