PracticeUpdate Cardiology March 2019

CONTENTS 3

TOP STORIES 2018 5 Aspirin Primary Prevention Trials By Joerg Herrmann MD 6 Are Omega-3 Fatty Acids Cardioprotective? It Depends…. By Peter Libby MD 7 Cardiovascular Outcome Studies: REDUCE-IT By Benjamin Morgan Scirica MD

RESEARCH Editor’s picks 8 Long-Term Prognosis and Outcome Predictors in Takotsubo Syndrome

Comment by Francesco Pelliccia MD, PhD

20 Target: Stroke Phase II Improves Door-to- Needle Times in Acute Ischemic Stroke 21 Late Thrombectomy for Stroke Linked With Better Quality of Life Outcomes in DEFUSE 3 21 Some Stroke Patients May Benefit From Thrombolysis Beyond Standard 4.5-Hour Time Window 22 Minimally Invasive Surgery May be Option for Intracranial Hemorrhage 9 Angiotensin Receptor Neprilysin Inhibitor for Functional Mitral Regurgitation Comment by Gervasio A. Lamas MD, FACC, FAHA, FESC 10 Circulating Blood-Based Biomarkers Associated With Prevalent Atrial Fibrillation Comment by Emile G. Daoud MD, FACC 11 Coronary Artery Plaque Characteristics Associated With Adverse Outcomes in the SCOT-HEART Study Comment by Stephan Achenbach Prof. Dr. med. 12 Intensive Blood Pressure Control Does Not Decrease Dementia Risk Comment by Clyde W. Yancy MD, MSc, MACC, FAHA, MACP, FHFSA 13 Impact of Atrial Fibrillation Ablation on Recurrent Hospitalization By Douglas P. Zipes MD 14 His Resynchronization vs Biventricular Pacing in Patients With Heart Failure and Left Bundle Branch Block Comment by Douglas P. Zipes MD 15 Workplace Bullying and Workplace Violence as Risk Factors for Cardiovascular Disease Comment by Viola Vaccarino MD, PhD

EXPERT OPINION 16

18 My Approach to Stem Cell Therapy for Heart Failure Patients: Not All Cells Are Created Equally By Eugenio Cingolani MD

Practical Considerations and Utility of SGLT2 Inhibitors in Improving CV Outcomes Interview with Silvio E. Inzucchi MD

19 Getting a B (as in Apolipoprotein B) Is Good Enough By Paul D. Thompson MD

CONFERENCE COVERAGE 20 International Stroke Conference 2019 By the PracticeUpdate Editorial Team

VOL. 4 • NO. 1 • 2019