SPSFAM EXPERT REVIEW PANEL

AOAC SPDS ERP REVIEW: MAIN FORM

Submission Date

2017-09-15 21:45:37

Name

Tom Seipelt

E-mail

tom.seipelt@abbott.com

Organization

Abbott Nutrition

Title of Method

Method for the determination of Bisphenol A in drinks by Fluorescence detection

AOAC Candidate Method Number (e.g. ALN-01)

BPA-03

Applicable SMPR

Bisphenol A (BPA)

Summary:

The method is applicable to the determination of bisphenol A (BPA) from soft drinks, foods, and other beverages with extraction and clean-up using SPE followed by HPLC with fluorescence detection. The specificity of the extraction is realized using a molecularly imprinted polymer which is selective for BPA and related compounds. Sensitivity from canned energy drinks is reported with an LOQ of 0.5 ug/L.

1. Does the applicability of the method support the applicability of the SMPR? If not, please explain what is missing. 2. Does the analytical technique(s) used in the method meet the SMPR? If not, please specify how it differs from what is stated in the SMPR. 3. Are the definitions specified in the SMPR used and applied appropriately in the method? If no, please indicate how the terms are used. 4. Does the method, as written, contain all appropriate precautions and warnings related to the method's reagents, components, instrumentation, or method steps that may be hazardous? If no, please suggest wording or option(s).

No. Data are shown for canned soft drinks, energy drinks, etc. but all requirements are not addressed for any single matrix type.

The data presented do not support meeting all aspects of the SMPR. For example, adequate LOQ is claimed for canned energy drinks, but the accuracy and precision do not meet SMPR for this matrix.

This is not clear. Method performance was stated "under conditions of RSDr", but the conditions of the experiment are not stated.

No, the method as presented does not contain a safety section that would address appropriate handling of acids or organic solvents. A safety section must be added to indicate the use of appropriate personal protective equipment like gloves and safety glasses.