Chemistry-PTM-OMA_Modules_1-4

Overview

• RMs, CRMs, and SRMs that are relevant matrixes can be used as test  materials in a validation study. • Reference standards can be used to prepare solutions to fortify  matrixes to specified analyte concentrations for use as test materials  in a validation study. • Reference methods applicable to the relevant matrixes can be used in  a method comparison validation study. • In rare cases, such as new or complex analytes, reference methods,  RMs, CRMs, SRMs, and reference standards may not be available. In  these cases, alternate strategies should be explored.