Chemistry-PTM-OMA_Modules_1-4

OMA Collaborative (MLV) Study Designs

Method Type # Valid Data Sets Study Design per Collaborator

Statistics

Recovery, bias, LOD, LOQ, s r , s R

Quantitative ≥8

≥5 Materials 2 Replicates per material

Qualitative

≥10

1 Matrix 12 Replicates High 12 Replicates Low (fractional pos.*) 12 Replicates Non‐spiked

LPOD s r

with 95% CI with 95% CI

s R

s L If method comparison:  dLPOD + CI (CI must include “0”)

*Fractional positives defined as LPOD = 0.25‐0.75