Chemistry-PTM-OMA_Modules_1-4

Preparation of Test Materials

• Obtain sufficient amount of single lot of matrix for candidate method analyses and  reference method analyses (if applicable) • Screen food item for endogenous analyte • Recommend using both the candidate and reference methods • Naturally contaminated or incurred matrices are preferred • If analyte not found, or the contamination level is too low, then fortify the matrix  with the target analyte. • Incorporate into matrix using an appropriate technique with appropriate holding conditions • Details are analyte/matrix dependent and will be specified in protocols • Analyte concentrations should cover the intended range of the candidate method