Chemistry-PTM-OMA_Modules_1-4

Plackett‐Burman Design

• W.J. and Steiner, E.H. (1975), Statistical Manual of the Association of  Official Analytical Chemists, p 50‐55. • Wernimont, Grant T. (1985), Use or Statistics to Develop and Evaluate  Analytical Methods, p 78‐82. • For each parameter, vary conditions above and below nominal test  conditions • For example, test 8 combinations of 7 parameters and analyze data by  parameter  • Study materials prepared in the same manner as the matrix study  materials