Chemistry-PTM-OMA_Modules_1-4

Robustness

Quantitative Methods • Use 1 test portion per treatment  combination • Analyze according to candidate  method with appropriate parameters  altered • Analyze data by appropriate data  analysis: ANOVA, multi‐factor  regression, or generalized linear  model software 

Qualitative Methods • Use 1 test material at analyte concentration that yields fractional  positives (2‐4 positives/5 replicates) • Test 5 replicates per treatment  combination • Use generalized linear model for data  analysis