Chemistry-PTM-OMA_Modules_1-4

Conclusions • Method developers should be encouraged that statistically significant  findings in this experiment are not indicative of a faulty method, and  the discovery of significance is not a roadblock to successful method  validation.  • Success of this experiment is not conditional on a conclusion of “no  significant differences were observed.” • Any findings at this stage may be used to modify method parameters,  emphasize areas of caution, or ease or tighten specific parameter  ranges.