2018 March 16 SPDS

Kava Chemotype

Fitness for Purpose As Agreed September 22, 2017

The method identifies and quantifies the six primary kavalactones  derived from the underground portions of kava ( Piper methysticum ),  namely desmethoxyangonin, dihydrokavain, yangonin, kavain,  dihydromethysticin, and methysticin in plant material, dietary  ingredients and dietary supplements. The method identifies and  quantifies flavokavains A, B, and C in kava plant material, dietary  supplements and dietary ingredients. Test results can be used in chemotype identification but this specific  determination is outside the method scope. Individual kavalactones  should be quantifiable within the range of 0.1 to 50 percent by weight in  forms that include liquid, soft, and dry extracts as well as in softgels,  capsules, and tablets in the presence of common excipients. The ability  to address kavalactones in beverages is an advantage but not a  requirement. No limit on analysis time is imposed.”