2018 March 16 SPDS

Table 1: Information on kavalactones and flavokavaines of interest.

CAS # (alternative)

#

Common Name

IUPAC Name

UNII Code

InChI Key

PubChem

(6 R )-5,6-Dihydro-4-methoxy-6-[(1 E )-2- phenylethenyl]-2 H -pyran-2-one

1

Kavain ((R)-(+)-Kavain)

500-64-1

W1ES06373M

XEAQIWGXBXCYFX-GUOLPTJISA-N

5281565

5,6-Dihydro-4-methoxy-6-[(1 E )-2-phenylethenyl]- 2 H -pyran-2-one (6 S )-5,6-dihydro-4-methoxy-6-(2-phenylethyl)-2 H - Pyran-2-one (6 R )-6-[(1 E )-2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6- dihydro-4-methoxy-2 H -pyran-2-one (6 S )-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro- 4-methoxy-2 H -pyran-2-one 4-Methoxy-6-[(1 E )-2-(4-methoxyphenyl)ethenyl]- 2 H -pyran-2-one 4-Methoxy-6-[(1 E )-2-phenylethenyl]-2 H -pyran-2- one (2 E )-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4- methoxyphenyl)-2-propen-1-one (2 E )-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenyl- 2-propen-1-one (2 E )-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4- hydroxyphenyl)-2-propen-1-one

3155-48-4 (1635-33-2)

2

d,l-Kavain

5L1NI60TGB

XEAQIWGXBXCYFX-BQYQJAHWSA-N

5369129

Dihydrokavain ((+)-( S )- Dihydrokavain, Marindinin) Methysticin ((+)-Methysticin, Kavahin) Dihydromethysticin (( S )-(+)- Dihydromethysticin) Desmethoxyyangonin (5,6- Dehydrokawain) Flavokavain A (Flavokawain A, 4- Methoxyflavokawain B) Flavokavain B (Flavokawain B, Persicochalcone) Flavokavain C (Flavokawain C, 4- Hydroxyflavokawain B) Yangonin

3

587-63-3

NW8ZGW9XRZ

VOOYTQRREPYRIW-LBPRGKRZSA-N

10220256

4

495-85-2

M832AIJ6HX

GTEXBOVBADJOQH-FWEMWIAWSA-N

5281567

5

19902-91-1

FZ66MQ73GS

RSIWXFIBHXYNFM-NSHDSACASA-N

88308

6

500-62-9

R970U49V3C

XLHIYUYCSMZCCC-VMPITWQZSA-N

5281575

15345-89-8 (1952-41-6) 37951-13-6 (3420-72-2) 1775-97-9 37308-75-1 (56798-34-6)

7

F2MBQ8QRUN

DKKJNZYHGRUXBS-BQYQJAHWSA-N

5273621

8

CGIBCVBDFUTMPT-RMKNXTFCSA-N

5355469

9

QKQLSQLKXBHUSO-CMDGGOBGSA-N

5356121

10

UXUFMIJZNYXWDX-VMPITWQZSA-N

6293081