2018 March 16 SPDS

Background: Resveratrol

Resveratrol Bioactivities In 1997, Pezzuto ( Science , 1987; 275: 218) discovered that resveratrol from grapes, berries and other sources had cancer chemoprevention activity through multiple mechanisms of action • anti-inflammation (inhibits COX, iNOS, and NF-κB) • anti-oxidation (upregulates quinone reductase, glutathione, superoxide dismutase, and catalase) • induction of apoptosis Subsequently, >20,000 papers have reported multiple other activities including • prevention of cardiovascular disease • anti-aging • neuroprotection

SMPR Key Points: Resveratrol

• The method must be specific for trans -resveratrol in the presence of the cis isomer in dietary supplements and dietary ingredients • Examples of dietary supplements and dietary ingredients containing resveratrol include • Powders • Tablets • Capsules • Liquids • Softgels • Extracts • Reference materials are available from multiple sources for trans- resveratrol, [d 4 ]- trans- resveratrol, and cis -resveratrol