Radiobiology 2016

Apoptotic index and prognosis in cancer All studies using morphology or TUNEL since 2000 (Wilson, 2003)

Cervix

author

n, treatment

result

comment

Jain

76, Rx

n.s.

no correlation with either p53 or bcl-2

Gasinska 130, Rx

n.s

AI/MI index significant

Lee Kim

86, ?

n.s.

correlation with progression, MVD, Ki-67 but not OS

42, Rx 77, Rx 40, Rx

sig sig sig

high AI poor LTC, OS

Liu

high AI (or Ki-67) poor OS no corr with IATs

Zaghloul

low AI poor OS (or high vascularity)

Results

Paxton 146, Rx

n.s.

high prolif or grade significant

NSCLC

Hanaoka 70, surg

n.s.

no correlation with bcl-2 or bax or ratio

Wang Hwang

58, surg 68, surg 6 better outcome with high AI

sig sig sig sig

low AI worse OS inverse correlation with bcl-2 and TA

low AI worse OS also high bcl-2 worse OS

Macluskey ?, ?

low AI worse OS

Langedijk

161, Rx

high AI worse LTC, OS no correlation with bcl-2

Breast

?, ? 8 worse outcome with igh AI sig high AI worse DFS, OS

Srinivas

Kato Ikpatt Villar

422, ? 585, ?

n.s

correlated with p53 and MI only MI and grade significant

n.s.

116, surg

sig

high AI worse survival inverse corr with bcl-2

82, ? 13 not significant n.s.

Lee Wu

positive correlation with PCNA low AI worse RFS and OS

91, CTX

sig sig sig

de Jong Lipponen

172, ? 288. ?

high AI worse OS positive correlation with MI

high AI worse OS

Rectum Sogawa

75, pre Rx

n.s. n.s.

AI increased after Rx but not correlated with OS

Schwander 160, surg

inverse correlation with p53 and bcl-2

Bladder

Giannopolou 53, ?

n.s

no correlation with pro-apoptotic proteins bax, FAS-R casp-3 high AI better LTC not OS, low AI shorter time to reccurrence

Moonen

83, Rx 55, Rx

n.s.

Lara

sig

low AI better LTC and OS

Esoph

Rees

58, Rx, CTX, surg n.s

only TOPO II and not AI or Ki-67 showed clinical utility

Shibata

72, surg

sig

high AI better OS