Radiobiology 2016

survival of HCT116 colorectal carcinoma cells (Chu, Dewey et al, 2004)

p21-/-

14-3-3σ-/-

p21-/-: ⬇ G1 arrest ⬆ survival • Death and removal of cells after irradiation may take many d ys or even weeks 14-3-3σ-/-: ⬇ late S/G2 arrest ⬇ survival • The type of cell death has no relation with sensitivity