Radiobiology 2016

Withers 1966: Skin remains intact if clonogen survival is higher than about 5 per 10 -6 per cm 2 . Higher doses will cause moist desquamation. Dose-response for skin epithelium

Dose-survival curves for mouse skin epithelial clonogenic (stem) cells in conditions of hyperbaric oxygen, air breathing or ischemic hypoxia induced by compression. skin and mucosa provide a reason for protracting radiation therapy over several weeks. Two clonally-derived islands of epithelium in a 1 cm diameter radiation-induced ulcer of the skin on the back of a mouse. Rapid regrowth on epithelial surfaces such as

20 days after 15Gy

hypoxia

air

oxygen