Radiobiology 2016

1/03/2016

Small bowel toxicity

• Acute toxicity

• Results of cell death in proliferative compartment • Failure to replace the villus epithelium • Shortening of the villus • Endothelial cell swelling and loss with increased vascular permeability • Breakdown of the mucosal barrier • Mucositis

Consequential late effects

Impairment of barrier function

Dörr, Radiother Oncol 2001

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