Radiobiology 2016

1/03/2016

Relevant factors • Radiobiological -related factors influencing normal tissue reactions • Intrinsic radiosensitivity (L2.3) • Total radiation dose (L3.5) • Technique and irradiated volume (L3.6) • Fractionation schedule (late reactions) (L2.3) • Overall treatment time (early reactions) (L2.4) • Concomitant treatment (L4.4, L5.2)

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Relevant radiobiological factors

26 patients derived fibroblasts Hierarchical clustering 3 x 3.5 Gy

• Intrinsic radiosensitivity

Sensitive profile

Alsner J Radiother Oncol 2007 26 pts

Resistant profile

Differential gene expression in irradiated fibroblasts between pts with variable risk of radiation-induced fibrosis

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